• Genome-wide risk prediction of common diseases across ancestries in one million people 

      Mars, Nina; Kerminen, Sini; Feng, Yen-Chen A.; Kanai, Masahiro; Läll, Kristi; Thomas, Laurent Francois; Skogholt, Anne Heidi; della Briotta Parolo, Pietro; Neale, Benjamin M.; Smoller, Jordan W.; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Mägi, Reedik; Matsuda, Koichi; Okada, Yukinori; Pirinen, Matti; Palotie, Aarno; Ganna, Andrea; Martin, Alicia R.; Ripatti, Samuli (Peer reviewed; Journal article, 2022)
      Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast and prostate cancer, we performed ...
    • Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts 

      Wang, Ying; Lopera, Esteban; Namba, Shinichi; Kerminen, Sini; Tsuo, Kristin; Läll, Kristi; Kanai, Masahiro; Zhou, Wei; Wu, Kuan-Han; Favé, Marie-Julie; Bhatta, Laxmi; Awadalla, Philip; Brumpton, Ben Michael; Deelen, Patrick; Hveem, Kristian; Faro, Valeria Lo; Mägi, Reedik; Murakami, Yoshinori; Sanna, Serena; Smoller, Jordan W.; Uzunovic, Jasmina; Wolford, Brooke N.; GBMI, .; Willer, Cristen; Gamazon, Eric R.; Cox, Nancy J.; Surakka, Ida; Okada, Yukinori; Martin, Alicia R.; Hirbo, Jibril B. (Peer reviewed; Journal article, 2023)
      Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data ...
    • Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease 

      Zhou, Wei; Kanai, Masahiro; Wu, Kuan-Han H.; Rasheed, Humaira; Tsuo, Kristin; Hirbo, Jibril B.; Wang, Ying; Bhattacharya, Arjun; Zhao, Huiling; Namba, Shinichi; Surakka, Ida; Wolford, Brooke; Lo Faro, Valeria; Lopera-Maya, Esteban A.; Läll, Kristi; Favé, Marie-Julie; Partanen, Juulia J.; Chapman, Sinéad B.; Karjalainen, Juha; Kurki, Mitja; Maasha, Mutaamba; Brumpton, Ben Michael; Chavan, Sameer; Chen, Tzu-Ting; Daya, Michelle; Ding, Yi; Feng, Yen-Chen A.; Guare, Lindsay A.; Gignoux, Christopher R.; Graham, Sarah E.; Hornsby, Whitney E.; Ingold, Nathan; Ismail, Said I.; Johnson, Ruth; Laisk, Triin; Lin, Kuang; Lv, Jun; Millwood, Iona Y.; Moreno-Grau, Sonia; Nam, Kisung; Palta, Priit; Pandit, Anita; Preuss, Michael H.; Saad, Chadi; Setia-Verma, Shefali; Thorsteinsdottir, Unnur; Uzunovic, Jasmina; Verma, Anurag; Zawistowski, Matthew; Zhong, Xue; Afifi, Nahla; Al-Dabhani, Kawthar M.; Al Thani, Asma; Bradford, Yuki; Campbell, Archie; Crooks, Kristy; de Bock, Geertruida H.; Damrauer, Scott M.; Douville, Nicholas J.; Finer, Sarah; Fritsche, Lars; Fthenou, Eleni; Gonzalez-Arroyo, Gilberto; Griffiths, Christopher J.; Guo, Yu; Hunt, Karen A.; Ioannidis, Alexander; Jansonius, Nomdo M.; Konuma, Takahiro; Lee, Ming Ta Michael; Lopez-Pineda, Arturo; Matsuda, Yuta; Marioni, Riccardo E.; Moatamed, Babak; Nava-Aguilar, Marco A.; Numakura, Kensuke; Patil, Snehal; Rafaels, Nicholas; Richmond, Anne; Rojas-Muñoz, Agustin; Shortt, Jonathan A.; Straub, Peter; Tao, Ran; Vanderwerff, Brett; Vernekar, Manvi; Veturi, Yogasudha; Barnes, Kathleen C.; Boezen, Marike; Chen, Zhengming; Chen, Chia-Yen; Cho, Judy; Smith, George Davey; Finucane, Hilary K.; Franke, Lude; Gamazon, Eric R.; Ganna, Andrea; Gaunt, Tom R.; Ge, Tian; Huang, Hailiang; Huffman, Jennifer; Katsanis, Nicholas; Koskela, Jukka T.; Lajonchere, Clara; Law, Matthew H.; Li, Liming; Lindgren, Cecilia M.; Loos, Ruth J.F.; MacGregor, Stuart; Matsuda, Koichi; Olsen, Catherine M.; Porteous, David J.; Shavit, Jordan A.; Snieder, Harold; Takano, Tomohiro; Trembath, Richard C.; Vonk, Judith M.; Whiteman, David C.; Wicks, Stephen J.; Wijmenga, Tjitske Nienke; Wright, John; Zheng, Jie; Zhou, Xiang; Awadalla, Philip; Boehnke, Michael; Bustamante, Carlos D.; Cox, Nancy J.; Fatumo, Segun; Geschwind, Daniel H.; Hayward, Caroline; Hveem, Kristian; Kenny, Eimear E.; Lee, Seunggeun; Lin, Yen-Feng; Mbarek, Hamdi; Mägi, Reedik; Martin, Hilary C.; Medland, Sarah E.; Okada, Yukinori; Palotie, Aarno V.; Pasaniuc, Bogdan; Rader, Daniel J.; Ritchie, Marylyn D.; Sanna, Serena; Smoller, Jordan W.; Stefansson, Kari; van Heel, David A.; Walters, Robin G.; Zöllner, Sebastian; Martin, Alicia R.; Willer, Cristen J.; Daly, Mark J.; Neale, Benjamin M. (Journal article; Peer reviewed, 2022)
    • Mapping genomic loci implicates genes and synaptic biology in schizophrenia 

      Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil; Bigdeli, Tim B.; Bryois, Julien; Chen, Chia-Yen; Dennison, Charlotte A.; Hall, Lynsey S.; Lam, Max; Watanabe, Kyoko; Frei, Oleksandr; Ge, Tian; Harwood, Janet C.; Koopmans, Frank; Magnusson, Sigurdur; Richards, Alexander L.; Sidorenko, Julia; Wu, Yang; Zeng, Jian; Grove, Jakob; Kim, Minsoo; Li, Zhiqiang; Voloudakis, Georgios; Zhang, Wen; Adams, Mark; Agartz, Ingrid; Atkinson, Elizabeth G.; Agerbo, Esben; Al Eissa, Mariam; Albus, Margot; Alexander, Madeline; Alizadeh, Behrooz Z.; Alptekin, Köksal; Als, Thomas D.; Amin, Farooq; Arolt, Volker; Arrojo, Manuel; Athanasiu, Lavinia; Azevedo, Maria Helena; Bacanu, Silviu A.; Bass, Nicholas J.; Begemann, Martin; Belliveau, Richard A.; Bene, Judit; Benyamin, Beben; Bergen, Sarah E.; Blasi, Giuseppe; Bobes, Julio; Bonassi, Stefano; Braun, Alice; Bressan, Rodrigo Affonseca; Bromet, Evelyn J.; Bruggeman, Richard; Buckley, Peter F.; Buckner, Randy L.; Bybjerg-Grauholm, Jonas; Cahn, Wiepke; Cairns, Murray J.; Calkins, Monica E.; Carr, Vaughan J.; Castle, David; Catts, Stanley V.; Chambert, Kimberley D.; Chan, Raymond C K; Chaumette, Boris; Cheng, Wei; Cheung, Eric F C; Chong, Siow Ann; Cohen, David; Consoli, Angèle; Cordeiro, Quirino; Costas, Javier; Curtis, Charles; Davidson, Michael; Davis, Kenneth L.; de Haan, Lieuwe; Degenhardt, Franziska; DeLisi, Lynn E.; Demontis, Ditte; Dickerson, Faith; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Duan, Jubao; Ducci, Giuseppe; Dudbridge, Frank; Eriksson, Johan G.; Fañanás, Lourdes; Faraone, Stephen; Fiorentino, Alessia; Forstner, Andreas; Frank, Josef; Freimer, Nelson B.; Fromer, Menachem; Frustaci, Alessandra; Gadelha, Ary; Genovese, Giulio; Gershon, Elliot S.; Giannitelli, Marianna; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; González Peñas, Javier; González-Pinto, Ana; Gopal, Srihari; Gratten, Jacob; Green, Michael F.; Greenwood, Tiffany A.; Guillin, Olivier; Gülöksüz, Sinan; Gur, Raquel E.; Gur, Ruben C.; Gutiérrez, Blanca; Hahn, Eric; Hakonarson, Hakon; Haroutunian, Vahram; Hartmann, Annette M.; Harvey, Carol; Hayward, Caroline; Henskens, Frans A.; Herms, Stefan; Hoffmann, Per; Howrigan, Daniel P.; Ikeda, Masashi; Iyegbe, Conrad; Joa, Inge; Julià, Antonio; Kähler, Anna Katarina; Kam-Thong, Tony; Kamatani, Yoichiro; Karachanak-Yankova, Sena; Kebir, Oussama; Keller, Matthew C.; Kelly, Brian J.; Khrunin, Andrey; Kim, Sung-Wan; Klovins, Janis; Kondratiev, Nikolay; Konte, Bettina; Kraft, Julia; Kubo, Michiaki; Kučinskas, Vaidutis; Kučinskiene, Zita Ausrele; Kusumawardhani, Agung; Kuzelova-Ptackova, Hana; Landi, Stefano; Lazzeroni, Laura C.; Lee, Phil H.; Legge, Sophie E.; Lehrer, Douglas S.; Lencer, Rebecca; Lerer, Bernard; Li, Miaoxin; Lieberman, Jeffrey; Light, Gregory A.; Limborska, Svetlana; Liu, Chih-Min; Lönnqvist, Jouko; Loughland, Carmel M.; Lubinski, Jan; Luykx, Jurjen J.; Lynham, Amy; Macek, Milan; Mackinnon, Andrew; Magnusson, Patrik K E; Maher, Brion S.; Maier, Wolfgang; Malaspina, Dolores; Mallet, Jacques; Marder, Stephen R.; Marsal, Sara; Martin, Alicia R.; Martorell, Lourdes; Mattheisen, Manuel; McCarley, Robert W.; McDonald, Colm; McGrath, John J.; Medeiros, Helena; Meier, Sandra; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mitjans, Marina; Molden, Espen; Molina, Esther; Molto, María Dolores; Mondelli, Valeria; Moreno, Carmen; Morley, Christopher P.; Muntané, Gerard; Murphy, Kieran C.; Myin-Germeys, Inez; Nenadić, Igor; Nestadt, Gerald; Nikitina-Zake, Liene; Noto, Cristiano; Nuechterlein, Keith H.; O'Brien, Niamh Louise; O'Neill, F Anthony; Oh, Sang-Yun; Olincy, Ann; Ota, Vanessa Kiyomi; Pantelis, Christos; Papadimitriou, George N.; Parellada, Mara; Paunio, Tiina; Pellegrino, Renata; Periyasamy, Sathish; Perkins, Diana O.; Pfuhlmann, Bruno; Pietiläinen, Olli; Pimm, Jonathan; Porteous, David; Powell, John; Quattrone, Diego; Quested, Digby; Radant, Allen D.; Rampino, Antonio; Rapaport, Mark H.; Rautanen, Anna; Reichenberg, Abraham; Roe, Cheryl; Roffman, Joshua L.; Roth, Julian; Rothermundt, Matthias; Rutten, Bart P F; Saker-Delye, Safaa; Salomaa, Veikko; Sanjuan, Julio; Santoro, Marcos Leite; Savitz, Adam; Schall, Ulrich; Scott, Rodney J.; Seidman, Larry J.; Sharp, Sally Isabel; Shi, Jianxin; Siever, Larry J.; Sigurdsson, Engilbert; Sim, Kang; Skarabis, Nora; Slominsky, Petr; So, Hon-Cheong; Sobell, Janet L.; Söderman, Erik; Stain, Helen J.; Steen, Nils Eiel; Steixner-Kumar, Agnes A.; Stögmann, Elisabeth; Stone, William S.; Straub, Richard E.; Streit, Fabian; Strengman, Eric; Stroup, T. Scott; Subramaniam, Mythily; Sugar, Catherine A.; Suvisaari, Jaana; Svrakic, Dragan M.; Swerdlow, Neal R.; Szatkiewicz, Jin P.; Ta, Thi Minh Tam; Takahashi, Atsushi; Terao, Chikashi; Thibaut, Florence; Toncheva, Draga; Tooney, Paul A.; Torretta, Silvia; Tosato, Sarah; Tura, Gian Battista; Turetsky, Bruce I.; Üçok, Alp; Vaaler, Arne; van Amelsvoort, Therese; van Winkel, Ruud; Veijola, Juha; Waddington, John; Walter, Henrik; Waterreus, Anna; Webb, Bradley T.; Weiser, Mark; Williams, Nigel M.; Witt, Stephanie H.; Wormley, Brandon K.; Wu, Jing Qin; Xu, Zhida; Yolken, Robert; Zai, Clement C.; Zhou, Wei; Zhu, Feng; Zimprich, Fritz; Atbaşoğlu, Eşref Cem; Ayub, Muhammad; Benner, Christian; Bertolino, Alessandro; Black, Donald W.; Bray, Nicholas J.; Breen, Gerome; Buccola, Nancy G.; Byerley, William F.; Chen, Wei J.; Cloninger, C Robert; Crespo-Facorro, Benedicto; Donohoe, Gary; Freedman, Robert; Galletly, Cherrie; Gandal, Michael J.; Gennarelli, Massimo; Hougaard, David M.; Hwu, Hai-Gwo; Jablensky, Assen V.; McCarroll, Steven A.; Moran, Jennifer L.; Mors, Ole; Mortensen, Preben B.; Müller-Myhsok, Bertram; Neil, Amanda L.; Nordentoft, Merete; Pato, Michele T.; Petryshen, Tracey L.; Pirinen, Matti; Pulver, Ann E.; Schulze, Thomas G.; Silverman, Jeremy M.; Smoller, Jordan W.; Stahl, Eli A.; Tsuang, Debby W.; Vilella, Elisabet; Wang, Shi-Heng; Xu, Shuhua; Adolfsson, Rolf; Arango, Celso; Baune, Bernhard T.; Belangero, Sintia Iole; Børglum, Anders D.; Braff, David; Bramon, Elvira; Buxbaum, Joseph D.; Campion, Dominique; Cervilla, Jorge A.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Curtis, David; Forti, Marta Di; Domenici, Enrico; Ehrenreich, Hannelore; Escott-Price, Valentina; Esko, Tõnu; Fanous, Ayman H.; Gareeva, Anna; Gawlik, Micha; Gejman, Pablo V.; Gill, Michael; Glatt, Stephen J.; Golimbet, Vera; Hong, Kyung Sue; Hultman, Christina M.; Hyman, Steven E.; Iwata, Nakao; Jönsson, Erik Gunnar; Kahn, René S; Kennedy, James L.; Khusnutdinova, Elza; Kirov, George; Knowles, James A.; Krebs, Marie-Odile; Laurent-Levinson, Claudine; Lee, Jimmy; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; Malhotra, Dheeraj; McIntosh, Andrew; McQuillin, Andrew; Menezes, Paulo R.; Morgan, Vera A.; Morris, Derek W.; Mowry, Bryan J.; Murray, Robin M.; Nimgaonkar, Vishwajit; Nöthen, Markus M.; Ophoff, Roel A.; Paciga, Sara A.; Palotie, Aarno; Pato, Carlos N.; Qin, Shengying; Rietschel, Marcella; Riley, Brien P.; Rivera, Margarita; Rujescu, Dan; Saka, Meram C.; Sanders, Alan R.; Schwab, Sibylle G.; Serretti, Alessandro; Sham, Pak C.; Shi, Yongyong; St Clair, David; Stefánsson, Hreinn; Stefansson, Kari; Tsuang, Ming T.; van Os, Jim; Vawter, Marquis P.; Weinberger, Daniel R.; Werge, Thomas; Wildenauer, Dieter B.; Yu, Xin; Yue, Weihua; Holmans, Peter A.; Pocklington, Andrew J.; Roussos, Panos; Vassos, Evangelos; Verhage, Matthijs; Visscher, Peter M.; Yang, Jian; Posthuma, Danielle; Andreassen, Ole; Kendler, Kenneth S.; Owen, Michael J.; Wray, Naomi R.; Daly, Mark J.; Huang, Hailiang; Neale, Benjamin M.; Sullivan, Patrick F.; Ripke, Stephan; Walters, James T R; O'Donovan, Michael C. (Peer reviewed; Journal article, 2022)
      Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control ...